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1 Introduction The glutathione peroxidase family (GPX) is a family of antioxidant enzymes that are an essential class of selenoenzymes in mammals ( 2 O 2 or organic hydroperoxides to water or corresponding alcohols, thereby mitigating their toxicity ( In mammals, GPX works with superoxide dismutase and catalase to form an enzymatic antioxidant system that reduces reactive oxygen species (ROS) and limits their toxicity

Data are from in vitro and in vivo (cell and animal) studies and cannot be extrapolated to humans .

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The in vivo relevance of necroptosis, NETs, and the alternative complement pathway, specifically the C5a-C5a receptor interaction, for disease induction was established in murine MPO-AAV models (135, 153155)